Neuroimmune Psychiatric Disorders (NIPD)

The Neuroimmune Psychiatric Disorders (NIPD) Clinic provides care for children, adolescents, and young adults with complex neurological and psychiatric disorders following an infection or in association with an immune disorder. Our team of providers works with a diverse group of specialties to help give our patients comprehensive care.

New patients

If you or your child should be seen in the NIPD Clinic, please have your primary care provider send a referral to our clinic. Once you have received your appointment, download the intake information form and age-appropriate questionnaire for your child below. Fill these out in advance and bring them to your child's first appointment with us.

Please refer to the following sections on this page:

Conditions we treat

We evaluate and treat the following conditions:

  • Childhood post-infectious autoimmune encephalopathy (CPAE) or pediatric autoimmune neuropsychiatric disorder (PANS)
  • Pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAS)
  • Post infectious neuropsychiatric or neuroinflammatory conditions in adolescents and adults
  • Neuropsychiatric illnesses associated with autoimmune conditions such as:
    • Inflammatory bowel disease
    • Lupus

What is PANS or PANDAS?

PANS are descriptive names for the same group of conditions. They happen when a child’s immune response to an infection causes inflammation in the brain. The inflammation can cause the sudden onset of behavioral, neurological, and personality changes. It's called 'sudden onset' because the changes occur quickly, usually within 2 to 3 days. These conditions are diagnosed in children aged 3 years to puberty. These sudden symptoms include one or both of the following:

  • Obsessive-compulsive disorder (OCD)
  • Avoidant restrictive food intake disorder (ARFID)

PANDAS is a subset of PANS where symptoms are triggered by a streptococcus infection, like strep throat. Children who have had a recent infection or illness are at the highest risk for any of these conditions - PANS or PANDAS. To be diagnosed with PANS or PANDAS, a child must have either OCD or ARFID and 2 or more of the following neuropsychiatric symptoms:

  • Anxiety (often social or separation)
  • Behavioral or developmental regression (for example, baby talk)
  • Change in school performance, ADHD-like symptoms, memory, and cognitive changes
  • Depression or mood swings
  • Irritability or aggression
  • Sensory or motor changes (for example, new tics)
  • Trouble sleeping, bedwetting, or urinary accidents

Our services

We focus on helping patients, their families, and physicians understand these complex conditions. Our team provides:

  • Comprehensive evaluation
  • Consultation
  • Ongoing care, if indicated
  • Treatments that incorporate medical and behavioral health including:
    • Managing medications
    • Preventing and treating infection and inflammation
    • Treating neuropsychiatric symptoms and providing family support with psychotherapy

As part of their evaluation or treatment your child may see providers from one or more of these specialties:

Additional resources

  • The Alex Manfull Fund supports awareness, education, and research to further understand the incidence, etiology, and best treatment of post-infectious neuroimmune disorders (aka PANDAS, PANS, and Autoimmune Encephalitis) with an emphasis on their manifestation in Adolescents and Young Adults.
  • Neuroimmune Foundation provides PANS and PANDAS resources for patients and families.
  • Pace Foundation


We focus on improving diagnosis and treatment for patients with neuroinflammatory conditions. Our program includes ongoing clinical, epidemiological, and basic science research into tests and treatments. We are part of the PANS Research Network, as well as the CPAE Clinics of Excellence Network.

Referrals and appointments

  • If your child is a returning patient: You may use myD-H to communicate securely with your child's providers, request or change appointments, review your child's medical record, and more.
  • If you are a health care professional: To make sure the child you are referring is seen in the NIPD Clinic, please make sure you include NIPD as part of the referral.

Our team

NIPD Clinic team